Developmental changes in brain network hub connectivity in late adolescence

STE Baker; DI Lubman; M Yücel; NB Allen; S Whittle; BD Fulcher; A Zalesky; A Fornito

Journal article

Developmental changes in brain network hub connectivity in late adolescence

STE Baker, DI Lubman, M Yücel, NB Allen, S Whittle, BD Fulcher, A Zalesky, A Fornito

Journal of Neuroscience | Published : 2015

DOI: 10.1523/JNEUROSCI.5043-14.2015

Abstract

The human brain undergoes substantial development throughout adolescence and into early adulthood. This maturational process is thought to include the refinement of connectivity between putative connectivity hub regions of the brain, which collectively form a dense core that enhances the functional integration of anatomically distributed, and functionally specialized, neural systems. Here, we used longitudinal diffusion magnetic resonance imaging to characterize changes in connectivity between 80 cortical and subcortical anatomical regions over a 2 year period in 31 adolescents between the ages of 15 and 19 years. Connectome-wide analysis indicated that only a small subset of connections sho..

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University of Melbourne Researchers

Nick Allen Author

Sarah Whittle Author

Andrew Zalesky Author

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Grants

Awarded by National Health and Medical Research Council [NHMRC]

Awarded by Australian Research Council (ARC)

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Career Development Fellowships

Awarded by NHMRC Early Career Fellowship

Awarded by ARC Future Fellowship

Awarded by NHMRC Project

Awarded by Australian Research Council

Awarded by National Health and Medical Research Council of Australia

Funding Acknowledgements

This research was supported by grants from the Colonial Foundation, the National Health and Medical Research Council [NHMRC (Australia); Program Grant 350241], and the Australian Research Council (ARC; Discovery Grants DP0878136 and DP1092637). S.T.E.B. is supported by an Australian Postgraduate Award. M.Y. is supported by a NHMRC Senior Research Fellowship (1021973). S.W. and A.Z. are supported by NHMRC Career Development Fellowships (1007716 to S.W. and 1047648 to A.Z.). B.D.F. is supported by a NHMRC Early Career Fellowship (1089718). A.F. is supported by an ARC Future Fellowship (FT130100589) and NHMRC Project Grants (1066779 and 1050504).